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I J,2d21, 1!. 42 AM {,:nm Unsafo an d.nofni:r ve MayoCrr.c <br />17. Singh D, et at Keeton (Mitragyna speciosa) dependencewithdawal symptoms and cravings in regular users. Drug <br />and Alcohol Dependence. 2014,139132. <br />18. Swagger MT, at at Kratom use and mental health A systematic review. Drug and Alcohol Dependence 2018,183.134_ <br />19. Food and Drug Administration. FDA investigates- multstahe outbreak of salmonella infecfior's linked to products reported <br />to contain kratom. rifts .//www_fda_gov/Food!Recalls OutbreaksEmergenees/Outbreaks/ucm597265. him_ Accessed <br />April 17, 2018. <br />20. Food and Drug Administration. Statement from FDA Commissioner Scott Gottlieb, MD., on FDA advisory abort deadly <br />risks associated with kratom_ haps'/www.fda.gov/NewsEverts/NewsmomlIF ressAnnouncements'ucrn584970_ him_ <br />Accessed April 17, 2018_ <br />21, Voelker R. CracKdDwn on false claims to ease opioid withdrawal symptoms -JAMA. 2018',319'.857. <br />22, Post S. Kratom exposures reported ro United States poison control centers. 2011-2017. Clinical Toxicology. Published <br />online February 20, 2013. <br />23. Drug Enforcement Administrat on. {ratom drug fad shent firms llwww.dea gov/site5idefaulVhles/2020-06/Kratcm- <br />2020.pdf. Accessed January 26. 2022. <br />24. Therapeutic Research Center Kratom otes lroaturalmedianes therapeutirresearch com/databases/focd,-herbs- <br />supplements/professional aspxcproductuizl513. Accessed January 28. 2022. <br />25. UmbehrG, at al. Acute liver injury following short-oFu- use or the herbal supplement kratom. JAAPA. 2,222,35.39. <br />June 03, 2022 <br />Original articlehitpsi/www. maga Uinic org/hcalthy-lifosryle/consumer-hoaith in-depth/kratom/art-20402171 <br />Any use of this site consfitutes your agreement to he Terms and Conditions and Privacy Policy linked below <br />Terms and Conditions <br />Privacy Policy <br />Notice of Privacy Practices <br />Notice of Nondiscrimination <br />Mayo Clinic is a nonprofit organization and proceeds from Won advedisirg help support our mission. Mayo Clinic does <br />rot endorse any of the third party products and services advent sed <br />Adverbsiina. and sponsorship policy <br />Advertising and s,ponsorshlpopportur ties <br />Asingle copy of these materials may be rennted for rcrcommercial personal use only. "Mayo ' "%layc Clinic," <br />"MayoClinic org," "Mayo Clinic Healthy oving." and the triple -shield Mayo Clirc logo are trademarks of Mayo Foundation <br />for Medical Education and Resea'ch. <br />s^ 1098-2022 Mayo Fou ndflbory 'cr Medical Edo( ahon and Researcry (MFMcR). All rights reserved_ <br />Crwti. -ocl, , o 5 11, e _. m, 1,,.I- -I Nka.ord i 4021 / to <br />